Inhibition of placental mTOR signaling provides a link between placental malaria and reduced birthweight.
Identifieur interne : 000807 ( Main/Exploration ); précédent : 000806; suivant : 000808Inhibition of placental mTOR signaling provides a link between placental malaria and reduced birthweight.
Auteurs : Kris Genelyn Dimasuay [Australie] ; Elizabeth H. Aitken [Australie] ; Fredrick Rosario [États-Unis] ; Madi Njie [Australie] ; Jocelyn Glazier [Royaume-Uni] ; Stephen J. Rogerson [Australie] ; Freya J I. Fowkes [Australie] ; James G. Beeson [Australie] ; Theresa Powell [États-Unis] ; Thomas Jansson [États-Unis] ; Philippe Boeuf [Australie]Source :
- BMC medicine [ 1741-7015 ] ; 2017.
Descripteurs français
- KwdFr :
- Complications parasitaires de la grossesse (métabolisme), Femelle (MeSH), Grossesse (MeSH), Humains (MeSH), Nourrisson à faible poids de naissance (MeSH), Nouveau-né (MeSH), Paludisme à Plasmodium falciparum (anatomopathologie), Paludisme à Plasmodium falciparum (complications), Paludisme à Plasmodium falciparum (métabolisme), Placenta (métabolisme), Placenta (parasitologie), Poids de naissance (physiologie), Sérine-thréonine kinases TOR (métabolisme), Transduction du signal (MeSH).
- MESH :
- anatomopathologie : Paludisme à Plasmodium falciparum.
- métabolisme : Complications parasitaires de la grossesse, Paludisme à Plasmodium falciparum, Placenta, Sérine-thréonine kinases TOR.
- parasitologie : Placenta.
- physiologie : Poids de naissance.
- Femelle, Grossesse, Humains, Nourrisson à faible poids de naissance, Nouveau-né, Transduction du signal.
English descriptors
- KwdEn :
- Birth Weight (physiology), Female (MeSH), Humans (MeSH), Infant, Low Birth Weight (MeSH), Infant, Newborn (MeSH), Malaria, Falciparum (complications), Malaria, Falciparum (metabolism), Malaria, Falciparum (pathology), Placenta (metabolism), Placenta (parasitology), Pregnancy (MeSH), Pregnancy Complications, Parasitic (metabolism), Signal Transduction (MeSH), TOR Serine-Threonine Kinases (metabolism).
- MESH :
- chemical , metabolism : TOR Serine-Threonine Kinases.
- complications : Malaria, Falciparum.
- metabolism : Malaria, Falciparum, Placenta, Pregnancy Complications, Parasitic.
- parasitology : Placenta.
- pathology : Malaria, Falciparum.
- physiology : Birth Weight.
- Female, Humans, Infant, Low Birth Weight, Infant, Newborn, Pregnancy, Signal Transduction.
Abstract
BACKGROUND
Placental Plasmodium falciparum malaria can trigger intervillositis, a local inflammatory response more strongly associated with low birthweight than placental malaria infection alone. Fetal growth (and therefore birthweight) is dependent on placental amino acid transport, which is impaired in placental malaria-associated intervillositis. Here, we tested the hypothesis that mechanistic target of rapamycin (mTOR) signaling, a pathway known to regulate amino acid transport, is inhibited in placental malaria-associated intervillositis, contributing to lower birthweight.
METHODS
We determined the link between intervillositis, mTOR signaling activity, and amino acid uptake in tissue biopsies from both uninfected placentas and malaria-infected placentas with and without intervillositis, and in an in vitro model using primary human trophoblast (PHT) cells.
RESULTS
We demonstrated that (1) placental mTOR activity is lower in cases of placental malaria with intervillositis, (2) placental mTOR activity is negatively correlated with the degree of inflammation, and (3) inhibition of placental mTOR activity is associated with reduced placental amino acid uptake and lower birthweight. In PHT cells, we showed that (1) inhibition of mTOR signaling is a mechanistic link between placental malaria-associated intervillositis and decreased amino acid uptake and (2) constitutive mTOR activation partially restores amino acid uptake.
CONCLUSIONS
Our data support the concept that inhibition of placental mTOR signaling constitutes a mechanistic link between placental malaria-associated intervillositis and decreased amino acid uptake, which may contribute to lower birthweight. Restoring placental mTOR signaling in placental malaria may increase birthweight and improve neonatal survival, representing a new potential therapeutic approach.
DOI: 10.1186/s12916-016-0759-3
PubMed: 28049467
PubMed Central: PMC5209943
Affiliations:
- Australie, Royaume-Uni, États-Unis
- Angleterre, Colorado, Grand Manchester, Victoria (État)
- Manchester, Melbourne
- Université de Manchester, Université de Melbourne
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Inhibition of placental mTOR signaling provides a link between placental malaria and reduced birthweight.</title><author><name sortKey="Dimasuay, Kris Genelyn" sort="Dimasuay, Kris Genelyn" uniqKey="Dimasuay K" first="Kris Genelyn" last="Dimasuay">Kris Genelyn Dimasuay</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine at Royal Melbourne Hospital, The University of Melbourne, Parkville, 3004, VIC, Australia. genelyn_dimasuay@yahoo.com.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medicine at Royal Melbourne Hospital, The University of Melbourne, Parkville, 3004, VIC</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Centre for Biomedical Research, Burnet Institute, 85 Commercial Road, Melbourne, 3004, VIC, Australia. genelyn_dimasuay@yahoo.com.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Biomedical Research, Burnet Institute, 85 Commercial Road, Melbourne, 3004, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Aitken, Elizabeth H" sort="Aitken, Elizabeth H" uniqKey="Aitken E" first="Elizabeth H" last="Aitken">Elizabeth H. Aitken</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine at Royal Melbourne Hospital, The University of Melbourne, Parkville, 3004, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medicine at Royal Melbourne Hospital, The University of Melbourne, Parkville, 3004, VIC</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Rosario, Fredrick" sort="Rosario, Fredrick" uniqKey="Rosario F" first="Fredrick" last="Rosario">Fredrick Rosario</name><affiliation wicri:level="2"><nlm:affiliation>Department of Obstetrics & Gynecology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Obstetrics & Gynecology, University of Colorado Anschutz Medical Campus, Aurora, CO</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Njie, Madi" sort="Njie, Madi" uniqKey="Njie M" first="Madi" last="Njie">Madi Njie</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine at Royal Melbourne Hospital, The University of Melbourne, Parkville, 3004, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medicine at Royal Melbourne Hospital, The University of Melbourne, Parkville, 3004, VIC</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Glazier, Jocelyn" sort="Glazier, Jocelyn" uniqKey="Glazier J" first="Jocelyn" last="Glazier">Jocelyn Glazier</name><affiliation wicri:level="4"><nlm:affiliation>Maternal and Fetal Health Research Centre, Division of Developmental Biology & Medicine, School of Medical Sciences, Faculty of Biology, Medicine & Health, University of Manchester, St. Mary's Hospital, Manchester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Maternal and Fetal Health Research Centre, Division of Developmental Biology & Medicine, School of Medical Sciences, Faculty of Biology, Medicine & Health, University of Manchester, St. Mary's Hospital, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region></placeName><orgName type="university">Université de Manchester</orgName></affiliation></author><author><name sortKey="Rogerson, Stephen J" sort="Rogerson, Stephen J" uniqKey="Rogerson S" first="Stephen J" last="Rogerson">Stephen J. Rogerson</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine at Royal Melbourne Hospital, The University of Melbourne, Parkville, 3004, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medicine at Royal Melbourne Hospital, The University of Melbourne, Parkville, 3004, VIC</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Fowkes, Freya J I" sort="Fowkes, Freya J I" uniqKey="Fowkes F" first="Freya J I" last="Fowkes">Freya J I. Fowkes</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Biomedical Research, Burnet Institute, 85 Commercial Road, Melbourne, 3004, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Biomedical Research, Burnet Institute, 85 Commercial Road, Melbourne, 3004, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Preventive Medicine, Department of Infectious Diseases, Monash University, Melbourne, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Epidemiology and Preventive Medicine, Department of Infectious Diseases, Monash University, Melbourne, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Beeson, James G" sort="Beeson, James G" uniqKey="Beeson J" first="James G" last="Beeson">James G. Beeson</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine at Royal Melbourne Hospital, The University of Melbourne, Parkville, 3004, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medicine at Royal Melbourne Hospital, The University of Melbourne, Parkville, 3004, VIC</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Centre for Biomedical Research, Burnet Institute, 85 Commercial Road, Melbourne, 3004, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Biomedical Research, Burnet Institute, 85 Commercial Road, Melbourne, 3004, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Central Clinical School, Monash University, Clayton, 3800, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Central Clinical School, Monash University, Clayton, 3800, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Powell, Theresa" sort="Powell, Theresa" uniqKey="Powell T" first="Theresa" last="Powell">Theresa Powell</name><affiliation wicri:level="2"><nlm:affiliation>Department of Obstetrics & Gynecology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Obstetrics & Gynecology, University of Colorado Anschutz Medical Campus, Aurora, CO</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Jansson, Thomas" sort="Jansson, Thomas" uniqKey="Jansson T" first="Thomas" last="Jansson">Thomas Jansson</name><affiliation wicri:level="2"><nlm:affiliation>Department of Obstetrics & Gynecology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Obstetrics & Gynecology, University of Colorado Anschutz Medical Campus, Aurora, CO</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Boeuf, Philippe" sort="Boeuf, Philippe" uniqKey="Boeuf P" first="Philippe" last="Boeuf">Philippe Boeuf</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine at Royal Melbourne Hospital, The University of Melbourne, Parkville, 3004, VIC, Australia. philippe.boeuf@burnet.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medicine at Royal Melbourne Hospital, The University of Melbourne, Parkville, 3004, VIC</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Centre for Biomedical Research, Burnet Institute, 85 Commercial Road, Melbourne, 3004, VIC, Australia. philippe.boeuf@burnet.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Biomedical Research, Burnet Institute, 85 Commercial Road, Melbourne, 3004, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, VIC, Australia. philippe.boeuf@burnet.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28049467</idno><idno type="pmid">28049467</idno><idno type="doi">10.1186/s12916-016-0759-3</idno><idno type="pmc">PMC5209943</idno><idno type="wicri:Area/Main/Corpus">000906</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000906</idno><idno type="wicri:Area/Main/Curation">000906</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000906</idno><idno type="wicri:Area/Main/Exploration">000906</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Inhibition of placental mTOR signaling provides a link between placental malaria and reduced birthweight.</title><author><name sortKey="Dimasuay, Kris Genelyn" sort="Dimasuay, Kris Genelyn" uniqKey="Dimasuay K" first="Kris Genelyn" last="Dimasuay">Kris Genelyn Dimasuay</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine at Royal Melbourne Hospital, The University of Melbourne, Parkville, 3004, VIC, Australia. genelyn_dimasuay@yahoo.com.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medicine at Royal Melbourne Hospital, The University of Melbourne, Parkville, 3004, VIC</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Centre for Biomedical Research, Burnet Institute, 85 Commercial Road, Melbourne, 3004, VIC, Australia. genelyn_dimasuay@yahoo.com.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Biomedical Research, Burnet Institute, 85 Commercial Road, Melbourne, 3004, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Aitken, Elizabeth H" sort="Aitken, Elizabeth H" uniqKey="Aitken E" first="Elizabeth H" last="Aitken">Elizabeth H. Aitken</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine at Royal Melbourne Hospital, The University of Melbourne, Parkville, 3004, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medicine at Royal Melbourne Hospital, The University of Melbourne, Parkville, 3004, VIC</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Rosario, Fredrick" sort="Rosario, Fredrick" uniqKey="Rosario F" first="Fredrick" last="Rosario">Fredrick Rosario</name><affiliation wicri:level="2"><nlm:affiliation>Department of Obstetrics & Gynecology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Obstetrics & Gynecology, University of Colorado Anschutz Medical Campus, Aurora, CO</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Njie, Madi" sort="Njie, Madi" uniqKey="Njie M" first="Madi" last="Njie">Madi Njie</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine at Royal Melbourne Hospital, The University of Melbourne, Parkville, 3004, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medicine at Royal Melbourne Hospital, The University of Melbourne, Parkville, 3004, VIC</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Glazier, Jocelyn" sort="Glazier, Jocelyn" uniqKey="Glazier J" first="Jocelyn" last="Glazier">Jocelyn Glazier</name><affiliation wicri:level="4"><nlm:affiliation>Maternal and Fetal Health Research Centre, Division of Developmental Biology & Medicine, School of Medical Sciences, Faculty of Biology, Medicine & Health, University of Manchester, St. Mary's Hospital, Manchester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Maternal and Fetal Health Research Centre, Division of Developmental Biology & Medicine, School of Medical Sciences, Faculty of Biology, Medicine & Health, University of Manchester, St. Mary's Hospital, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region></placeName><orgName type="university">Université de Manchester</orgName></affiliation></author><author><name sortKey="Rogerson, Stephen J" sort="Rogerson, Stephen J" uniqKey="Rogerson S" first="Stephen J" last="Rogerson">Stephen J. Rogerson</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine at Royal Melbourne Hospital, The University of Melbourne, Parkville, 3004, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medicine at Royal Melbourne Hospital, The University of Melbourne, Parkville, 3004, VIC</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Fowkes, Freya J I" sort="Fowkes, Freya J I" uniqKey="Fowkes F" first="Freya J I" last="Fowkes">Freya J I. Fowkes</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Biomedical Research, Burnet Institute, 85 Commercial Road, Melbourne, 3004, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Biomedical Research, Burnet Institute, 85 Commercial Road, Melbourne, 3004, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Preventive Medicine, Department of Infectious Diseases, Monash University, Melbourne, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Epidemiology and Preventive Medicine, Department of Infectious Diseases, Monash University, Melbourne, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Beeson, James G" sort="Beeson, James G" uniqKey="Beeson J" first="James G" last="Beeson">James G. Beeson</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine at Royal Melbourne Hospital, The University of Melbourne, Parkville, 3004, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medicine at Royal Melbourne Hospital, The University of Melbourne, Parkville, 3004, VIC</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Centre for Biomedical Research, Burnet Institute, 85 Commercial Road, Melbourne, 3004, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Biomedical Research, Burnet Institute, 85 Commercial Road, Melbourne, 3004, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Central Clinical School, Monash University, Clayton, 3800, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Central Clinical School, Monash University, Clayton, 3800, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Powell, Theresa" sort="Powell, Theresa" uniqKey="Powell T" first="Theresa" last="Powell">Theresa Powell</name><affiliation wicri:level="2"><nlm:affiliation>Department of Obstetrics & Gynecology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Obstetrics & Gynecology, University of Colorado Anschutz Medical Campus, Aurora, CO</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Jansson, Thomas" sort="Jansson, Thomas" uniqKey="Jansson T" first="Thomas" last="Jansson">Thomas Jansson</name><affiliation wicri:level="2"><nlm:affiliation>Department of Obstetrics & Gynecology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Obstetrics & Gynecology, University of Colorado Anschutz Medical Campus, Aurora, CO</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Boeuf, Philippe" sort="Boeuf, Philippe" uniqKey="Boeuf P" first="Philippe" last="Boeuf">Philippe Boeuf</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine at Royal Melbourne Hospital, The University of Melbourne, Parkville, 3004, VIC, Australia. philippe.boeuf@burnet.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medicine at Royal Melbourne Hospital, The University of Melbourne, Parkville, 3004, VIC</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Centre for Biomedical Research, Burnet Institute, 85 Commercial Road, Melbourne, 3004, VIC, Australia. philippe.boeuf@burnet.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Biomedical Research, Burnet Institute, 85 Commercial Road, Melbourne, 3004, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, VIC, Australia. philippe.boeuf@burnet.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author></analytic><series><title level="j">BMC medicine</title><idno type="eISSN">1741-7015</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Birth Weight (physiology)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Infant, Low Birth Weight (MeSH)</term><term>Infant, Newborn (MeSH)</term><term>Malaria, Falciparum (complications)</term><term>Malaria, Falciparum (metabolism)</term><term>Malaria, Falciparum (pathology)</term><term>Placenta (metabolism)</term><term>Placenta (parasitology)</term><term>Pregnancy (MeSH)</term><term>Pregnancy Complications, Parasitic (metabolism)</term><term>Signal Transduction (MeSH)</term><term>TOR Serine-Threonine Kinases (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Complications parasitaires de la grossesse (métabolisme)</term><term>Femelle (MeSH)</term><term>Grossesse (MeSH)</term><term>Humains (MeSH)</term><term>Nourrisson à faible poids de naissance (MeSH)</term><term>Nouveau-né (MeSH)</term><term>Paludisme à Plasmodium falciparum (anatomopathologie)</term><term>Paludisme à Plasmodium falciparum (complications)</term><term>Paludisme à Plasmodium falciparum (métabolisme)</term><term>Placenta (métabolisme)</term><term>Placenta (parasitologie)</term><term>Poids de naissance (physiologie)</term><term>Sérine-thréonine kinases TOR (métabolisme)</term><term>Transduction du signal (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>TOR Serine-Threonine Kinases</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Paludisme à Plasmodium falciparum</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Malaria, Falciparum</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Malaria, Falciparum</term><term>Placenta</term><term>Pregnancy Complications, Parasitic</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Complications parasitaires de la grossesse</term><term>Paludisme à Plasmodium falciparum</term><term>Placenta</term><term>Sérine-thréonine kinases TOR</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Placenta</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Placenta</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Malaria, Falciparum</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Poids de naissance</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Birth Weight</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Humans</term><term>Infant, Low Birth Weight</term><term>Infant, Newborn</term><term>Pregnancy</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Femelle</term><term>Grossesse</term><term>Humains</term><term>Nourrisson à faible poids de naissance</term><term>Nouveau-né</term><term>Transduction du signal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Placental Plasmodium falciparum malaria can trigger intervillositis, a local inflammatory response more strongly associated with low birthweight than placental malaria infection alone. Fetal growth (and therefore birthweight) is dependent on placental amino acid transport, which is impaired in placental malaria-associated intervillositis. Here, we tested the hypothesis that mechanistic target of rapamycin (mTOR) signaling, a pathway known to regulate amino acid transport, is inhibited in placental malaria-associated intervillositis, contributing to lower birthweight.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>We determined the link between intervillositis, mTOR signaling activity, and amino acid uptake in tissue biopsies from both uninfected placentas and malaria-infected placentas with and without intervillositis, and in an in vitro model using primary human trophoblast (PHT) cells.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>We demonstrated that (1) placental mTOR activity is lower in cases of placental malaria with intervillositis, (2) placental mTOR activity is negatively correlated with the degree of inflammation, and (3) inhibition of placental mTOR activity is associated with reduced placental amino acid uptake and lower birthweight. In PHT cells, we showed that (1) inhibition of mTOR signaling is a mechanistic link between placental malaria-associated intervillositis and decreased amino acid uptake and (2) constitutive mTOR activation partially restores amino acid uptake.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Our data support the concept that inhibition of placental mTOR signaling constitutes a mechanistic link between placental malaria-associated intervillositis and decreased amino acid uptake, which may contribute to lower birthweight. Restoring placental mTOR signaling in placental malaria may increase birthweight and improve neonatal survival, representing a new potential therapeutic approach.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">28049467</PMID><DateCompleted><Year>2017</Year><Month>05</Month><Day>31</Day></DateCompleted><DateRevised><Year>2020</Year><Month>01</Month><Day>11</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1741-7015</ISSN><JournalIssue CitedMedium="Internet"><Volume>15</Volume><Issue>1</Issue><PubDate><Year>2017</Year><Month>Jan</Month><Day>03</Day></PubDate></JournalIssue><Title>BMC medicine</Title><ISOAbbreviation>BMC Med</ISOAbbreviation></Journal><ArticleTitle>Inhibition of placental mTOR signaling provides a link between placental malaria and reduced birthweight.</ArticleTitle><Pagination><MedlinePgn>1</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s12916-016-0759-3</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Placental Plasmodium falciparum malaria can trigger intervillositis, a local inflammatory response more strongly associated with low birthweight than placental malaria infection alone. Fetal growth (and therefore birthweight) is dependent on placental amino acid transport, which is impaired in placental malaria-associated intervillositis. Here, we tested the hypothesis that mechanistic target of rapamycin (mTOR) signaling, a pathway known to regulate amino acid transport, is inhibited in placental malaria-associated intervillositis, contributing to lower birthweight.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We determined the link between intervillositis, mTOR signaling activity, and amino acid uptake in tissue biopsies from both uninfected placentas and malaria-infected placentas with and without intervillositis, and in an in vitro model using primary human trophoblast (PHT) cells.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">We demonstrated that (1) placental mTOR activity is lower in cases of placental malaria with intervillositis, (2) placental mTOR activity is negatively correlated with the degree of inflammation, and (3) inhibition of placental mTOR activity is associated with reduced placental amino acid uptake and lower birthweight. In PHT cells, we showed that (1) inhibition of mTOR signaling is a mechanistic link between placental malaria-associated intervillositis and decreased amino acid uptake and (2) constitutive mTOR activation partially restores amino acid uptake.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Our data support the concept that inhibition of placental mTOR signaling constitutes a mechanistic link between placental malaria-associated intervillositis and decreased amino acid uptake, which may contribute to lower birthweight. Restoring placental mTOR signaling in placental malaria may increase birthweight and improve neonatal survival, representing a new potential therapeutic approach.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dimasuay</LastName><ForeName>Kris Genelyn</ForeName><Initials>KG</Initials><AffiliationInfo><Affiliation>Department of Medicine at Royal Melbourne Hospital, The University of Melbourne, Parkville, 3004, VIC, Australia. genelyn_dimasuay@yahoo.com.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Biomedical Research, Burnet Institute, 85 Commercial Road, Melbourne, 3004, VIC, Australia. genelyn_dimasuay@yahoo.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aitken</LastName><ForeName>Elizabeth H</ForeName><Initials>EH</Initials><AffiliationInfo><Affiliation>Department of Medicine at Royal Melbourne Hospital, The University of Melbourne, Parkville, 3004, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rosario</LastName><ForeName>Fredrick</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Obstetrics & Gynecology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Njie</LastName><ForeName>Madi</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Medicine at Royal Melbourne Hospital, The University of Melbourne, Parkville, 3004, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Glazier</LastName><ForeName>Jocelyn</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Maternal and Fetal Health Research Centre, Division of Developmental Biology & Medicine, School of Medical Sciences, Faculty of Biology, Medicine & Health, University of Manchester, St. Mary's Hospital, Manchester, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rogerson</LastName><ForeName>Stephen J</ForeName><Initials>SJ</Initials><AffiliationInfo><Affiliation>Department of Medicine at Royal Melbourne Hospital, The University of Melbourne, Parkville, 3004, VIC, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fowkes</LastName><ForeName>Freya J I</ForeName><Initials>FJ</Initials><AffiliationInfo><Affiliation>Centre for Biomedical Research, Burnet Institute, 85 Commercial Road, Melbourne, 3004, VIC, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology and Preventive Medicine, Department of Infectious Diseases, Monash University, Melbourne, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beeson</LastName><ForeName>James G</ForeName><Initials>JG</Initials><AffiliationInfo><Affiliation>Department of Medicine at Royal Melbourne Hospital, The University of Melbourne, Parkville, 3004, VIC, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Biomedical Research, Burnet Institute, 85 Commercial Road, Melbourne, 3004, VIC, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Microbiology and Central Clinical School, Monash University, Clayton, 3800, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Powell</LastName><ForeName>Theresa</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Obstetrics & Gynecology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jansson</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Obstetrics & Gynecology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boeuf</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-5851-3373</Identifier><AffiliationInfo><Affiliation>Department of Medicine at Royal Melbourne Hospital, The University of Melbourne, Parkville, 3004, VIC, Australia. philippe.boeuf@burnet.edu.au.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Biomedical Research, Burnet Institute, 85 Commercial Road, Melbourne, 3004, VIC, Australia. philippe.boeuf@burnet.edu.au.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, VIC, Australia. philippe.boeuf@burnet.edu.au.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 HD068370</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UL1 TR001082</GrantID><Acronym>TR</Acronym><Agency>NCATS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>01</Month><Day>03</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>BMC Med</MedlineTA><NlmUniqueID>101190723</NlmUniqueID><ISSNLinking>1741-7015</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>EC 2.7.1.1</RegistryNumber><NameOfSubstance UI="C546842">MTOR protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.1.1</RegistryNumber><NameOfSubstance UI="D058570">TOR Serine-Threonine Kinases</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D001724" MajorTopicYN="N">Birth Weight</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007230" MajorTopicYN="N">Infant, Low Birth Weight</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007231" MajorTopicYN="N">Infant, Newborn</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016778" MajorTopicYN="N">Malaria, Falciparum</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010920" MajorTopicYN="N">Placenta</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000469" MajorTopicYN="N">parasitology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011247" MajorTopicYN="N">Pregnancy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015597" MajorTopicYN="N">Pregnancy Complications, Parasitic</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="Y">Signal Transduction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058570" MajorTopicYN="N">TOR Serine-Threonine Kinases</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Deptor</Keyword><Keyword MajorTopicYN="Y">Fetal growth restriction</Keyword><Keyword MajorTopicYN="Y">Intervillositis</Keyword><Keyword MajorTopicYN="Y">System A transporter</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>08</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>11</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>1</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>1</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>6</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28049467</ArticleId><ArticleId IdType="doi">10.1186/s12916-016-0759-3</ArticleId><ArticleId IdType="pii">10.1186/s12916-016-0759-3</ArticleId><ArticleId IdType="pmc">PMC5209943</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Endocrinology. 1986 Apr;118(4):1567-82</Citation><ArticleIdList><ArticleId IdType="pubmed">3512258</ArticleId></ArticleIdList></Reference><Reference><Citation>Pediatr Res. 1997 Oct;42(4):514-9</Citation><ArticleIdList><ArticleId IdType="pubmed">9380446</ArticleId></ArticleIdList></Reference><Reference><Citation>J Mol Cell Biol. 2009 Dec;1(2):61-3</Citation><ArticleIdList><ArticleId IdType="pubmed">19706736</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2011 Mar 21;6(3):e17894</Citation><ArticleIdList><ArticleId IdType="pubmed">21445305</ArticleId></ArticleIdList></Reference><Reference><Citation>Diabetologia. 2015 Oct;58(10):2307-16</Citation><ArticleIdList><ArticleId IdType="pubmed">26099855</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Sci (Lond). 2016 Apr 1;130(7):499-512</Citation><ArticleIdList><ArticleId IdType="pubmed">26608079</ArticleId></ArticleIdList></Reference><Reference><Citation>J Nutr. 2016 Mar;146(3):532-41</Citation><ArticleIdList><ArticleId IdType="pubmed">26865647</ArticleId></ArticleIdList></Reference><Reference><Citation>Biol Reprod. 2015 Feb;92(2):49</Citation><ArticleIdList><ArticleId IdType="pubmed">25395678</ArticleId></ArticleIdList></Reference><Reference><Citation>J Nutr. 2010 Jul;140(7):1242-8</Citation><ArticleIdList><ArticleId IdType="pubmed">20505020</ArticleId></ArticleIdList></Reference><Reference><Citation>Parasitology. 2014 Apr;141(5):602-13</Citation><ArticleIdList><ArticleId IdType="pubmed">24476686</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Trop Med Hyg. 2003 Jan;68(1):115-9</Citation><ArticleIdList><ArticleId IdType="pubmed">12556159</ArticleId></ArticleIdList></Reference><Reference><Citation>Front Physiol. 2016 Jan 29;7:12</Citation><ArticleIdList><ArticleId IdType="pubmed">26858656</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Glob Health. 2014 Aug;2(8):e460-7</Citation><ArticleIdList><ArticleId IdType="pubmed">25103519</ArticleId></ArticleIdList></Reference><Reference><Citation>Infect Immun. 2003 Jan;71(1):267-70</Citation><ArticleIdList><ArticleId IdType="pubmed">12496175</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Sci (Lond). 2015 Dec;129(12 ):1131-41</Citation><ArticleIdList><ArticleId IdType="pubmed">26374858</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Obstet Gynecol. 2013 Sep;56(3):591-601</Citation><ArticleIdList><ArticleId IdType="pubmed">23703224</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Endocrinol. 2014 Apr;28(4):512-24</Citation><ArticleIdList><ArticleId IdType="pubmed">24606127</ArticleId></ArticleIdList></Reference><Reference><Citation>Cochrane Database Syst Rev. 2014 Oct 10;(10):CD000169</Citation><ArticleIdList><ArticleId IdType="pubmed">25300703</ArticleId></ArticleIdList></Reference><Reference><Citation>Amino Acids. 2015 Jun;47(6):1183-92</Citation><ArticleIdList><ArticleId IdType="pubmed">25740606</ArticleId></ArticleIdList></Reference><Reference><Citation>J Anim Sci. 2011 Jul;89(7):2017-30</Citation><ArticleIdList><ArticleId IdType="pubmed">21169511</ArticleId></ArticleIdList></Reference><Reference><Citation>Diabetes. 2002 Jul;51(7):2214-9</Citation><ArticleIdList><ArticleId IdType="pubmed">12086952</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2007 May 31;356(22):2271-81</Citation><ArticleIdList><ArticleId IdType="pubmed">17538086</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 2003 Oct 1;188(7):1074-82</Citation><ArticleIdList><ArticleId IdType="pubmed">14513430</ArticleId></ArticleIdList></Reference><Reference><Citation>Endocrinology. 2011 Mar;152(3):1119-29</Citation><ArticleIdList><ArticleId IdType="pubmed">21285325</ArticleId></ArticleIdList></Reference><Reference><Citation>J Nutr. 2012 Jan;142(1):173S-7S</Citation><ArticleIdList><ArticleId IdType="pubmed">22157540</ArticleId></ArticleIdList></Reference><Reference><Citation>Nutrition. 1997 Sep;13(9):807-13</Citation><ArticleIdList><ArticleId IdType="pubmed">9290095</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell. 2011 Oct 21;44(2):304-16</Citation><ArticleIdList><ArticleId IdType="pubmed">22017876</ArticleId></ArticleIdList></Reference><Reference><Citation>J Matern Fetal Neonatal Med. 2004 Jun;15(6):363-6</Citation><ArticleIdList><ArticleId IdType="pubmed">15280105</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2011 Feb 10;364(6):514-23</Citation><ArticleIdList><ArticleId IdType="pubmed">21306238</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Infect Dis. 2007 Feb;7(2):93-104</Citation><ArticleIdList><ArticleId IdType="pubmed">17251080</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Pathog. 2013 Feb;9(2):e1003153</Citation><ArticleIdList><ArticleId IdType="pubmed">23408887</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2012 May 02;485(7396):109-13</Citation><ArticleIdList><ArticleId IdType="pubmed">22552098</ArticleId></ArticleIdList></Reference><Reference><Citation>Amino Acids. 2013 Aug;45(2):241-56</Citation><ArticleIdList><ArticleId IdType="pubmed">23732998</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Physiol Cell Physiol. 2009 Jan;296(1):C142-50</Citation><ArticleIdList><ArticleId IdType="pubmed">18987252</ArticleId></ArticleIdList></Reference><Reference><Citation>Placenta. 2006 Apr;27 Suppl A:S91-7</Citation><ArticleIdList><ArticleId IdType="pubmed">16442615</ArticleId></ArticleIdList></Reference><Reference><Citation>J Physiol. 2013 Feb 1;591(3):609-25</Citation><ArticleIdList><ArticleId IdType="pubmed">23165769</ArticleId></ArticleIdList></Reference><Reference><Citation>Placenta. 2015 Jul;36(7):709-15</Citation><ArticleIdList><ArticleId IdType="pubmed">25972077</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Gynaecol Obstet. 2005 Jan;88(1):15-8</Citation><ArticleIdList><ArticleId IdType="pubmed">15617699</ArticleId></ArticleIdList></Reference><Reference><Citation>Malar J. 2013 Nov 15;12:421</Citation><ArticleIdList><ArticleId IdType="pubmed">24237643</ArticleId></ArticleIdList></Reference><Reference><Citation>J Nutr Biochem. 2012 Sep;23(9):1178-83</Citation><ArticleIdList><ArticleId IdType="pubmed">22137265</ArticleId></ArticleIdList></Reference><Reference><Citation>Front Oncol. 2014 Apr 14;4:64</Citation><ArticleIdList><ArticleId IdType="pubmed">24782981</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 2009 May 29;137(5):873-86</Citation><ArticleIdList><ArticleId IdType="pubmed">19446321</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochem Soc Trans. 2009 Feb;37(Pt 1):295-8</Citation><ArticleIdList><ArticleId IdType="pubmed">19143650</ArticleId></ArticleIdList></Reference><Reference><Citation>J Physiol. 2006 Nov 1;576(Pt 3):935-46</Citation><ArticleIdList><ArticleId IdType="pubmed">16916910</ArticleId></ArticleIdList></Reference><Reference><Citation>Trends Parasitol. 2010 Aug;26(8):412-9</Citation><ArticleIdList><ArticleId IdType="pubmed">20605743</ArticleId></ArticleIdList></Reference><Reference><Citation>J Nutr. 2012 May;142(5):924-30</Citation><ArticleIdList><ArticleId IdType="pubmed">22457392</ArticleId></ArticleIdList></Reference><Reference><Citation>Placenta. 2012 Nov;33 Suppl 2:e23-9</Citation><ArticleIdList><ArticleId IdType="pubmed">22687819</ArticleId></ArticleIdList></Reference><Reference><Citation>Sci Signal. 2011 Feb 22;4(161):ra10</Citation><ArticleIdList><ArticleId IdType="pubmed">21343617</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Colorado</li><li>Grand Manchester</li><li>Victoria (État)</li></region><settlement><li>Manchester</li><li>Melbourne</li></settlement><orgName><li>Université de Manchester</li><li>Université de Melbourne</li></orgName></list><tree><country name="Australie"><region name="Victoria (État)"><name sortKey="Dimasuay, Kris Genelyn" sort="Dimasuay, Kris Genelyn" uniqKey="Dimasuay K" first="Kris Genelyn" last="Dimasuay">Kris Genelyn Dimasuay</name></region><name sortKey="Aitken, Elizabeth H" sort="Aitken, Elizabeth H" uniqKey="Aitken E" first="Elizabeth H" last="Aitken">Elizabeth H. Aitken</name><name sortKey="Beeson, James G" sort="Beeson, James G" uniqKey="Beeson J" first="James G" last="Beeson">James G. Beeson</name><name sortKey="Beeson, James G" sort="Beeson, James G" uniqKey="Beeson J" first="James G" last="Beeson">James G. Beeson</name><name sortKey="Beeson, James G" sort="Beeson, James G" uniqKey="Beeson J" first="James G" last="Beeson">James G. Beeson</name><name sortKey="Boeuf, Philippe" sort="Boeuf, Philippe" uniqKey="Boeuf P" first="Philippe" last="Boeuf">Philippe Boeuf</name><name sortKey="Boeuf, Philippe" sort="Boeuf, Philippe" uniqKey="Boeuf P" first="Philippe" last="Boeuf">Philippe Boeuf</name><name sortKey="Boeuf, Philippe" sort="Boeuf, Philippe" uniqKey="Boeuf P" first="Philippe" last="Boeuf">Philippe Boeuf</name><name sortKey="Dimasuay, Kris Genelyn" sort="Dimasuay, Kris Genelyn" uniqKey="Dimasuay K" first="Kris Genelyn" last="Dimasuay">Kris Genelyn Dimasuay</name><name sortKey="Fowkes, Freya J I" sort="Fowkes, Freya J I" uniqKey="Fowkes F" first="Freya J I" last="Fowkes">Freya J I. Fowkes</name><name sortKey="Fowkes, Freya J I" sort="Fowkes, Freya J I" uniqKey="Fowkes F" first="Freya J I" last="Fowkes">Freya J I. Fowkes</name><name sortKey="Fowkes, Freya J I" sort="Fowkes, Freya J I" uniqKey="Fowkes F" first="Freya J I" last="Fowkes">Freya J I. Fowkes</name><name sortKey="Njie, Madi" sort="Njie, Madi" uniqKey="Njie M" first="Madi" last="Njie">Madi Njie</name><name sortKey="Rogerson, Stephen J" sort="Rogerson, Stephen J" uniqKey="Rogerson S" first="Stephen J" last="Rogerson">Stephen J. Rogerson</name><name sortKey="Rogerson, Stephen J" sort="Rogerson, Stephen J" uniqKey="Rogerson S" first="Stephen J" last="Rogerson">Stephen J. Rogerson</name></country><country name="États-Unis"><region name="Colorado"><name sortKey="Rosario, Fredrick" sort="Rosario, Fredrick" uniqKey="Rosario F" first="Fredrick" last="Rosario">Fredrick Rosario</name></region><name sortKey="Jansson, Thomas" sort="Jansson, Thomas" uniqKey="Jansson T" first="Thomas" last="Jansson">Thomas Jansson</name><name sortKey="Powell, Theresa" sort="Powell, Theresa" uniqKey="Powell T" first="Theresa" last="Powell">Theresa Powell</name><name sortKey="Powell, Theresa" sort="Powell, Theresa" uniqKey="Powell T" first="Theresa" last="Powell">Theresa Powell</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Glazier, Jocelyn" sort="Glazier, Jocelyn" uniqKey="Glazier J" first="Jocelyn" last="Glazier">Jocelyn Glazier</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Bois/explor/RapamycinFungusV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000807 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000807 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Bois
|area= RapamycinFungusV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:28049467
|texte= Inhibition of placental mTOR signaling provides a link between placental malaria and reduced birthweight.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:28049467" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a RapamycinFungusV1
| This area was generated with Dilib version V0.6.38. |  |